There's no one best set/rep scheme for every goal, but there are plenty of great plans to choose from, all time-tested and proven to work. Heavy, low rep work like 10 x 1, 5 x 2, and ramping up to a 2 or 3RM work great for pure strength gains. "Waves" and "ratchet loading" are also effective methods. For gaining size and strength, the classic 5 x 5 stands tall, but working with 2 to 6 reps and using techniques like clusters and contrast sets also work. For pure muscle gain, use volume in a moderate rep range and shorten the rest periods. 4x8, 6x6, and 10/8/6/20 have been around forever and continue to pack on muscle. I personally like to go over 12 reps with medium weight for endurance purposes in a lot of my exercises, both in the gym and in the track.
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